RHU « CirB–RNA » ANR–17–RHUS–0003We invite you to join us for the “International Workshop on Viral Biomarkers” organized by Pr. Zoulim in the framework of the RHU CirB–RNA funded by ANR (Agence Nationale de Recherche).
This event will take place on September 7, 2023 in Lyon at the “Hangar du Premier Film” of the Institut Lumière.
This event will take place on September 7, 2023 in Lyon at the “Hangar du Premier Film” of the Institut Lumière.
Free but Mandatory Registration before September 1 st , 2023
To register, please send an email to: CirB–RNA2023@inserm.fr
To register, please send an email to: CirB–RNA2023@inserm.fr
Program
9:30 am – 9:45 am Welcome: Fabien Zoulim, Massimo Levrero, Marintha Heil
9:45 am – 10:15 am Opening lecture: Why do we need novel biomarkers for the clinical development of HBV cure therapies? Anna Lok (USA) – 30 min (presentation and discussion)
10:15 am Molecular virology and Biomarkers Chairs: Christian Bréchot (USA), Walter Koch (USA)
10:15 am – 10:40 am The molecular biology of HBV RNAs: insights on new biomarkers Massimo Levrero (Lyon, France) – 25 min (presentation and discussion)
10:40 am – 11:05 am New insight on HBV particle trafficking Eberhard Hildt (Langen, Germany) – 25 min (presentation and discussion)
11:05 am – 11:20 am Characterization of circulating HBV RNAs in hepatocyte cell lines Alexia Paturel (Lyon, France) – 15 min (presentation and discussion)
11:20 am – 11:35 am Characterization of circulating HBV RNAs in CHB patients and mechanism of
cellular export Doohyun Kim (Lyon, France) – 15 min (presentation and discussion)
11:35 am – 11:50 am Coffee break (15 min)
11:50 am Assay development Chairs: Gilles Wandeler (Switzerland), Barbara Testoni (France)
11:50 am – 12:15 pm From discovery of biomarkers to assay development Walter Koch (USA) – 25 min (presentation and discussion)
12:15 pm – 12:40 pm Development of assays for the quantification of circulating HBV RNA Marintha Heil (Roche, USA) – 25 min (presentation and discussion)
12:40 pm – 1:45 pm Lunch Break (65 min)
Assay development(continued)
1:45 pm – 2:00 pm Validation of the investigational assay in clinical cohorts Caroline Scholtès (Lyon, France) – 15 min (presentation and discussion)
2:00 pm – 2:15 pm Novel assays for the quantification of HBV RNA species Aaron Hamilton (Roche, USA) – 15 min (presentation and discussion)
2:15 pm Clinical utility of novel HBV biomarkers Chairs: Anna Lok (USA), Antonio Craxi (Italy)
2:15 pm – 2:40 pm Prediction of outcome after cessation of nucleos(t)ide analog therapy Sabela Lens (Barcelona, Spain) – 25 min (presentation and discussion)
2:40 pm – 3:05 pm Investigation of viral biomarkers in clinical trials of novel antiviral strategies Fabien Zoulim (Lyon, France) – 25 min (presentation and discussion)
3:05 pm – 3:20 pm Coffee break (15 min)
Clinical utility of novel HBV biomarkers (continued)
3:20 pm – 3:40 pm Are serum HBV RNAs and HBcrAg non–invasive markers of intrahepatic
cccDNA? Barbara Testoni (Lyon, France) – 20 min (presentation and discussion)
3:40 pm – 4:00 pm Serum HBV RNAs and HBcrAg in HIV–HBV co–infected patients with HBV
functional cure Lorin Begré (Bern, Switzerland) – 20 min (presentation and discussion)
4:00 pm – 4:20 pm Serum HBV RNAs and HBcrAg in HBV–HDV co–infected patients Pietro Lampertico (Milan, Italy) – 20 min (presentation and discussion)
4:20 pm – 4:45 pm Closing lecture: The role of new viral biomarkers to assist the clinical
development of HBV cure strategies. The industry perspective. Rob Elston (GSK, UK) – 25 min (presentation and discussion)
4:45 pm – 5:00 pm Farewell Fabien Zoulim, Massimo Levrero, Marintha Heil
11:50 am – 12:15 pm From discovery of biomarkers to assay development Walter Koch (USA) – 25 min (presentation and discussion)
12:15 pm – 12:40 pm Development of assays for the quantification of circulating HBV RNA Marintha Heil (Roche, USA) – 25 min (presentation and discussion)
12:40 pm – 1:45 pm Lunch Break (65 min)
Assay development(continued)
1:45 pm – 2:00 pm Validation of the investigational assay in clinical cohorts Caroline Scholtès (Lyon, France) – 15 min (presentation and discussion)
2:00 pm – 2:15 pm Novel assays for the quantification of HBV RNA species Aaron Hamilton (Roche, USA) – 15 min (presentation and discussion)
2:15 pm Clinical utility of novel HBV biomarkers Chairs: Anna Lok (USA), Antonio Craxi (Italy)
2:15 pm – 2:40 pm Prediction of outcome after cessation of nucleos(t)ide analog therapy Sabela Lens (Barcelona, Spain) – 25 min (presentation and discussion)
2:40 pm – 3:05 pm Investigation of viral biomarkers in clinical trials of novel antiviral strategies Fabien Zoulim (Lyon, France) – 25 min (presentation and discussion)
3:05 pm – 3:20 pm Coffee break (15 min)
Clinical utility of novel HBV biomarkers (continued)
3:20 pm – 3:40 pm Are serum HBV RNAs and HBcrAg non–invasive markers of intrahepatic
cccDNA? Barbara Testoni (Lyon, France) – 20 min (presentation and discussion)
3:40 pm – 4:00 pm Serum HBV RNAs and HBcrAg in HIV–HBV co–infected patients with HBV
functional cure Lorin Begré (Bern, Switzerland) – 20 min (presentation and discussion)
4:00 pm – 4:20 pm Serum HBV RNAs and HBcrAg in HBV–HDV co–infected patients Pietro Lampertico (Milan, Italy) – 20 min (presentation and discussion)
4:20 pm – 4:45 pm Closing lecture: The role of new viral biomarkers to assist the clinical
development of HBV cure strategies. The industry perspective. Rob Elston (GSK, UK) – 25 min (presentation and discussion)
4:45 pm – 5:00 pm Farewell Fabien Zoulim, Massimo Levrero, Marintha Heil
We invite you to join us for the “International Workshop on Viral Biomarkers” organized by Pr Zoulim in the framework of the RHU CirB–RNA funded by ANR (Agence Nationale de Recherche).
This event will take place on September 7, 2023 in Lyon at the “Hangar du Premier Film” of the Institut Lumière.
Registration Form
• Last name:
• First name:
• Institution/Company:
• Department/Service:
• City, Country:
• Professional phone number:
• Professional email:
Deadline for registration: September 1 st , 2023
Please, send the registration form to: CirB–RNA2023@inserm.fr
